Siepel works in the area where
computer science, statistics,
evolutionary biology, and genomics
meet. His main focus is on
developing computational methods for
the identification of
novel functional elements in the
human genome, including genes,
regulatory elements, and structural
RNAs. His general approach is to
model the evolution and function of
DNA sequences simultaneously, so
that functional elements can be
identified by their evolutionary
signatures, and at the same time,
the detailed evolutionary histories
of these elements can be
reconstructed. Before completing his
PhD at University of California
Santa Cruz, Siepel worked for
several years as a software
developer. He has written widely
used computer programs for the
detection of evolutionarily
conserved elements, gene prediction,
phylogenetic modeling, and the
detection of recombinant HIV
sequences.