Project Description
FaST-LMM (Factored Spectrally Transformed
Linear Mixed Models) is a program for
performing genome-wide association studies (GWAS) on large data sets. It runs on
both Windows and Linux system, and has been tested on data sets with over
120,000 individuals [1,2].
FaST-LMM-Set extends the capabilities of FaST-LMM to handle associations between
sets of variants and phenotype [3].
You can read about FaST-LMM and FaST-LMM-Set in the following papers:
-
J. Listgarten*, C. Lippert*, C.M. Kadie,
R.I. Davidson, E. Eskin, and D. Heckerman*.
Improved linear mixed models for genome-wide association studies.
Nature Methods, 9: 525-526, June 2012 (doi:10.1038/nmeth.2037).
(*equal contributions)
-
C. Lippert*, J. Listgarten*, Y. Liu,
C.M. Kadie, R.I. Davidson, and D. Heckerman*.
FaST linear mixed models for genome-wide association studies. Nature
Methods, 8: 833-835, Oct 2011 (doi:10.1038/nmeth.1681).
(*equal contributions)
-
J. Listgarten*, C. Lippert*, Eun Youg Kang,
Jing Xiang, Carl M. Kadie, and D. Heckerman*.
A powerful and efficient set test for genetic markers that handles confounders.
Bioinformatics, 29:1526-1533, April 2013 (doi:10.1093/bioinformatics/btt177).
(*equal contributions)
General Info
The current released FaST-LMM program is available in three forms:
Windows binary,
Linux binary, and
Source.
Each form includes the license and manual.
Previous releases are also available (not recommended for use):
FaST-LMM v2.04:
Windows binary,
Linux binary,
Source.
FaST-LMM v2.03:
Windows binary,
Linux binary,
Source.
FaST-LMM v2.02:
Windows binary,
Linux binary,
Source.
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