His main research interest is in functional programming languages, their implementation, and their application. He has led a succession of research projects focused around the design and implementation of production-quality functional-language systems for both uniprocessors and parallel machines. He was a key contributor to the design of the now-standard functional language Haskell, and is the lead designer of the widely-used Glasgow Haskell Compiler (GHC). He has written two textbooks about the implementation of functional languages.
More generally, he is interested in language design, rich type systems, software component architectures, compiler technology, code generation, runtime systems, virtual machines, and garbage collection. He is particularly motivated by direct use of principled theory to practical language design and implementation -- that's one reason he loves functional programming so much.
His home page is at http://research.microsoft.com/~simonpj.