This project develops an approach for constructing dynamic models of gene regulatory networks from simple computational elements. While traditional approaches require fixing the network topology beforehand, the modularity of our approach allows us to pass easily from a basic first-level description of a biological system to more refined models. As an illustrative application we study the design principles for constructing robust, stochastic cellular clocks from genetic building blocks.
- Ralf Blossey, Interdisciplinary Research Institute, Lille.
- Ralf Blossey, Luca Cardelli, and Andrew Phillips, Compositionality, Stochasticity and Cooperativity in Dynamic Models of Gene Regulation, in HFSP Journal, vol. 2, no. 1, pp. 17–28, HFSP Publishing, February 2008.
- Ralf Blossey, Luca Cardelli, and Andrew Phillips, A Compositional Approach to the Stochastic Dynamics of Gene Networks, in Transactions in Computational Systems Biology, vol. 3939, no. 3939, pp. 99–122, Springer, January 2006.