Modelling of Circadian Oscillator Networks
Circadian oscillators provide rhythmic temporal cues for a range of biological processes in animals and plants, enabling anticipation of the day/night cycle and enhancing fitness. Near 24 h oscillations are maintained at the gene transcription level, which integrate environmental cues such as light and temperature and internal cues such as metabolism and signalling. Characterising these interactions is vital for understanding how physiology is optimised with respect to the time of day.
People
- Neil Dalchau, Microsoft Research
- Alex Webb, University of Cambridge
- Guy-Bart Stan, Imperial College London
Publications
- Alberto Carignano, Ye Yuan, Neil Dalchau, Alex AR Webb, and Jorge M Goncalves, Understanding and predicting biological networks using linear system identification, in Systems and Synthetic Biology: A Systematic Approach (In press), Springer, 2013
- Neil Dalchau, Understanding biological timing using mechanistic and black-box models, in New Phytologist, vol. 193, no. 4, pp. 852-858, March 2012
- Neil Dalchau, Seong Jin Baek, Helen M Briggs, Fiona C Robertson, Antony N Dodd, Michael J Gardner, Matthew A Stancombe, Michael J Haydon, Guy-Bart Stan, Jorge M Goncalves, and Alex AR Webb, The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose, in PNAS, vol. 108, no. 12, pp. 5104-5109, Proceedings of the National Academy of Sciences, 22 March 2011
- Neil Dalchau and Alex AR Webb, Ticking over - Circadian systems across the kingdoms of life, in Biochemist, vol. 33, no. 1, 1 February 2011
- Neil Dalchau, Katharine E Hubbard, Fiona C Robertson, Carlos T Hotta, Helen M Briggs, Guy-Bart Stan, Jorge M Goncalves, and Alex A R Webb, Correct biological timing in Arabidopsis requires multiple light signaling pathways, in PNAS, vol. 107, no. 29, pp. 13171-13176, Proceedings of the National Academy of Sciences, 1 July 2010
- Katharine E Hubbard, Fiona C Robertson, Neil Dalchau, and Alex A R Webb, Systems analyses of circadian networks., in Molecular Biosystems, vol. 5, pp. 1502-1511, 3 August 2009
- Neil Dalchau, Mathematical modelling of circadian signalling in Arabidopsis, December 2008
- Antony N Dodd, Michael J Gardner, Carlos T Hotta, Katharine E Hubbard, Neil Dalchau, John Love, Jean-Maurice Assie, Fiona C Robertson, Mia Kyed Jakobsen, Jorge Gonçalves, Dale Sanders, and Alex A R Webb, The Arabidopsis circadian clock incorporates a cADPR-based feedback loop., in Science, vol. 318, no. 5857, pp. 1789–1792, American Association for the Advancement of Science, 14 December 2007
- Carlos T Hotta, Michael J Gardner, Katharine E Hubbard, Seong Jin Baek, Neil Dalchau, Dontamala Suhita, Antony N Dodd, and Alex A R Webb, Modulation of environmental responses of plants by circadian clocks., in Plant Cell Environ, vol. 30, no. 3, pp. 333–349, March 2007
- Katharine E Hubbard, Carlos T Hotta, Michael J Gardner, Seong Jin Baek, Neil Dalchau, Suhita Dontamala, Antony N. Dodd, and Alex AR Webb, Circadian Rhythms in Stomata: Physiological and Molecular Aspects, pp. 157–177, Springer-Verlag, 2007
