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Microsoft Biology Foundation 2.0

The Microsoft Biology Foundation (MBF) 2.0 beta is a language-neutral bioinformatics tool kit built as an extension to the Microsoft .NET Framework. It implements a range of parsers for common bioinformatics file formats; a range of algorithms for manipulating DNA, RNA, and protein sequences; and a set of connectors to biological web services such as the U.S. National Center for Biotechnology Information’s Basic Local Alignment Search Tool. MBF is available under an Open Systems Interconnection model-approved open-source license, and executable, source code, demo applications, and documentation are freely downloadable.


File NameBio.msi
VersionBeta 1
Date Published7 April 2011
Download Size15.77 MB

Note By installing, copying, or otherwise using this software, you agree to be bound by the terms of its license. Read the license.

New Features

Here’s what’s new in this release:

  • Increased capacity for de novo assembly of larger and more complex species than version 1.0
  • Addition of comparative assembly functions for characterizing genetic diversity within or between species
  • Core object model improvements for smaller memory footprint and increased parallel processing
  • Parity with all version 1.0 tools and features
  • Documentation updates

System Requirements

To run this software, you need the following:

  • Windows XP with Service Pack (SP) 3 or later
  • Microsoft .NET Framework version 4.0

Installation Instructions

  1. Copy the MBF installer to a folder on your hard drive.
  2. Navigate to that folder and double-click Setup_Framework.msi, which runs the installation wizard.
  3. Follow the directions in the installation wizard to install MBF.

The MBF installer creates a directory named C:\Program Files (x86)\Microsoft Biology Initiative\0.2\MBF that contains the following:

  • \Addin
    • \PaDeNa.dll
    • \Pamsam.dll
  • \Doc
    • MBF_Overview.docx
    • MBF_Programming_Guide.docx
    • MBF_Sequence_Assembler.docx
    • MBF_PaDeNA.docx
  • Bio.dll
  • WebServiceHandlers.dll

If you install the optional SDK, the installer creates an SDK folder in the MBF folder that contains the following:

  • \SDK
    • \Samples
      • \IronPython
      • \SequenceSimulator
      • \TridentWorkflows
    • BioDotNet.chm

For more information, see MBF documentation.