Genomics in Healthcare
Using Microsoft technology to deliver the promise of the genome revolution to patients
The Human Genome was completed in 2001; however, the availability of genomic information has not yet translated into benefits in routine medical care.
We are creating and delivering technologies and toolsets for the bioinformatics and translational medicine communities to use at all stages of the research pipeline, from DNA sequencing to patient care.
Projects
- Computational Biology in the Microsoft Research eScience Group
Using machine learning and visualization tools developed at Microsoft, we are building maps of the with-individual evolution of HIV. Biologists are using these maps to identify candidates for good and bad epitopes. These candidates can then be evaluated with laboratory tests. - Genome-Wide Association Studies
Collaborative partner research teams are investigating what the genome tells us about health.- A Universal Data Format for Genotype Microarrays
- Genome-wide Association Study of Amyotrophic Lateral Sclerosis in Finland
- Pathway-based Association: A New Paradigm for Genome-wide Association Studies
- Data Quality Management for Model Improvement in GWAS
- Phenotypic Pipeline for Genome-wide Association Studies
- Applying Microsoft Research machine learning to diabetes, asthma, ALS, HIV, and malaria
- Building a systems biology toolkit on the .NET platform
- Advancing genome analysis tools by using Windows HPC
- Developing a genome browser by using Silverlight
- Creating tools for RNA analysis
- Applying F# for Scientists
- Bioinformatics – Selected Projects
- Collaborative Molecular Modeling Environment
Peter Kuhn, Scripps Research Institute - Computational Tools for Population Biology
Tanya Berger-Wolf, University of Illinois at Chicago - Microsoft Research Support for iGEM
Randy Rettberg, Massachusetts Institute of Technology - SQL Server-Based Comparative Analysis of RNA Sequences, Structures, and Evolution
Robin Gutell, University of Texas at Austin
- Collaborative Molecular Modeling Environment
Research Tools and Services
- The Microsoft Biology Foundation
- Computational Biology Software and Tools
- Database, HPC, and Cloud Services for Scientists
- Managing Scientific Workflows
- Microsoft Computational Biology Web Tools
- Vaccine Development Tools on CodePlex Open Source Project
- More advanced research tools and services...
Publications
- Computational Biology Publications, Computational Biological Sciences Group, Microsoft Research, Cambridge, UK
- Computational Aspects of Biological Information (Research Channel presentations)
- CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Kiepiela, et al., Nature Medicine, December 17, 2006
- Dynameomics: A multi-dimensional analysis-optimized database for dynamic protein data. Ozer, et al., Protein Engineering Design & Selection, 2008, 21: 379-386, 2008
See Microsoft Case Study - Founder effects in the assessment of HIV polymorphisms and HLA allele associations. Bhattacharya, et al., Science, 315, 1583-1586, March 16, 2007
- Global Public Health Informatics Bibliography (Global Partners in Public Health Informatics)
Health and WellBeing Topics
- Devices, Sensors, and Mobility
- Genomics in Healthcare
- Health and Wellbeing Papers and Presentations
- Case Studies
