Using touch screens presents a number of usability and accessibility challenges for people with disabilities. This talk demonstrates the possibilities of redesigning gesture-based user interfaces to enable people with disabilities to effectively use touch screens. I will describe several formative studies that have explored the interaction challenges that occur when people with disabilities use touch screens. I will then introduce several design prototypes which use accessible gestures to improve access to touch screens on mobile devices, tabletop computers, and public information kiosks. This research has been conducted primarily with two user groups: people with visual impairments, and older adults with multiple impairments.