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Epigenome-wide association studies without the need for cell-type composition

James Zou, Christoph Lippert, David Heckerman, Martin Ayree, and Jennifer Listgarten

Abstract

In epigenome-wide association studies, cell-type composition often differs between cases and controls, yielding associations that simply tag cell type rather than reveal fundamental biology. Current solutions require actual or estimated cell-type composition—information not easily obtainable for many samples of interest. We propose a method, FaST-LMM-EWASher, that automatically corrects for cell-type composition without the need for explicit knowledge of it, and then validate our method by comparison with the state-of-the-art approach. Corresponding software is available from http://www.microsoft.com/science/.

Details

Publication typeArticle
Published inNature Methods
PublisherNature Publishing Group
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