Predictive Modelling of Stem Cell Differentiation and Apoptosis in C. elegans

The nematode Caenorhabditis elegans has been established as a

modeling organism in biomedical research for several decades. Its

hermaphrodite germ line encompasses key developmental concepts like stem

cell differentiation and apoptosis; therefore it provides a good model system for

these basic concepts. Here, we have extended and refined our previous

computational model, which encompasses developmental landmarks and the

resulting movement of germ cells along the gonadal tube. We have used the

molecular dynamics (MD) framework to model the physical movement of cells

due to the force arising from cell divisions. The model simulation was

calibrated with experimental time and it is in accordance with experimental

observations. In addition, the model provides means for testing hypotheses

regarding the behaviour of mutated germ lines and the potential mechanisms

causing physiological apoptosis, which are difficult to assess experimentally.

IPCAT_12.pdf
PDF file

In  9th International Conference on Information Processing in Cells and Tissues (IPCAT), LNCS 7223, pp. 99–104

Publisher  Springer Verlag

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