Antony N Dodd, Michael J Gardner, Carlos T Hotta, Katharine E Hubbard, Neil Dalchau, John Love, Jean-Maurice Assie, Fiona C Robertson, Mia Kyed Jakobsen, Jorge Gonçalves, Dale Sanders, and Alex A R Webb
14 December 2007
Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.
In Science
Publisher American Association for the Advancement of Science
Copyright © 2007 by the American Association for the Advancement of Science. All rights reserved.
Details
| Type | Article |
| URL | http://www.sciencemag.org/cgi/content/abstract/318/5857/1789 |
| Pages | 1789–1792 |
| Volume | 318 |
| Number | 5857 |
| Institution | Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK. |
