The Arabidopsis circadian clock incorporates a cADPR-based feedback loop.

Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.

In  Science

Publisher  American Association for the Advancement of Science
Copyright © 2007 by the American Association for the Advancement of Science. All rights reserved.

Details

TypeArticle
URLhttp://www.sciencemag.org/cgi/content/abstract/318/5857/1789
Pages1789–1792
Volume318
Number5857
InstitutionDepartment of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK.
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